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it is extremely unlikely that sasuke could have beaten itachi if he wasnt sick and at full power. itachi was the uchiha prodigy and also has commented on by several ver powerful ninja in the series that he was one of the most powerful shinobi in generations and had limitless potential. Madara also stated that if Itachi had been healthy and serious, Sasuke would have lost.
(well no matter what codision itachi would be he would have died it was his decision after all)