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Hernán Cortés died in Castilleja de la Cuesta on December 2, 1547, from a case of Pleurisy (also known as pleuritis) is an inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. Among other things, infections are the most common cause of pleurisy.
The inflamed pleural layers rub against each other every time the lungs expand to breathe in air. This can cause sharp pain with inspiration(also called pleuritic chest pain).