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to obtain the mangekyou, one must experience the loss of a loved one and the emotion loss would activate it. for example itachi killing shusui, his best friend or sasuke killing his brother itachi

it is unknown how kakashi gained the mangekyou sharingan as he states himself that everyone close to him is dead. it is speculated that he evoked the emotions of when he lost his loved ones and through that process he obtained the mangekyou during the time skip.

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