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If you mean Vault 87 you should have noticed the door is "INACSESSIBLE", however if you turn your colison off by using console commands (only on PC version of F3) you can type in "tlc" and walk right through the door leading into a short cave that takes you out of the map.
If you want to actually go into the vault and open the entrance door you must download a mod from fallout3nexus.com
Hope this helps!