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If you mean the second time when he's about to take off in his airplane, First run to all of the pillars and switch of the lights after that find the RPG which is located at one of the corners on the first level. When all the lights are of you should be able to suprise him with the RPG shot, when he has lost track of you, as soon as you've shot it drop it and shoot it while he's struggling with it. after it has blown up run forward too him and hit the X button to restrain him and the second player will inject him with the virus, remember the one who's injecting the virus has to be against Wesker while the second player is holding his arms. If you fail to do this or would miss the RPG shot there should be 5-6 RPG shots on the 3rd floor.