Losing weight on your thighs is just like losing weight on any other part of your body. Exercise is the key! Try walking at a brisk pace three times a week for at least half an hour. Limit the amount of sugars and starches at night to cut down the amount of fat build up in your body. Drink lots of water. Work your way up to a jog if possible and keep up with the routine and you should see some results within a month. If you get bored find a friend to walk with and you both can benefit from the exercise routine.