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There are a large number of endings in Fallout 3, though most of them have relatively trivial differences in them. There are, however, three "major" determining factors in the sort of ending you get 1) Karma (good/evil/neutral) 2) Who got sent in the purifier (you/Lyons/neither) 3) Whether you decided to use the modified FEV (yes/no)

This would mean that there are about 18 "major" endings, which some of the slides changing based on what sidequest that you did over the course of the story, along with other various factors.

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