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Males reach sexual maturity around 9 months of age, but are not physically mature until 18-24 months of age, and should not be used for breeding until physically mature. Females becomes sexually mature when they experience their first heat cycle, around 7-12 months of age. Females should not be bred until physically mature, around 18-24 months of age, as a litter is physically and mentally draining and could harm your dog if she's too young. Toy breeds tend to become sexually mature a few months earlier than large or giant breeds.