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It highly depends on when and who does it. If a medical professional does it to prepare you for a colonoscopy or surgery then it is safe however if it's done by yourself or by someone else for reasons such as cleaning out your bowels of toxins then not really especially if you do it with herbs or coffee as some people do. There have been deaths linked to using coffee as a colon cleanser. If you wish to get a colon cleansing then seek advice from a medical professional.