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Yes. In the episode "Let's go to the Hop" Peter and Lois discuss Chris' alleged drug problem and wholesome values while putting on bondage costumes; then Lois proclaims that "the safety word is 'banana'", Peter replies with "I love you" and Lois punches him in the face. In 'Breaking out is Hard to Do', Lois is shown putting out cigarettes on her arm. In 'North by North Quahog' Lois talks about an earlier encouter 'Oh the rugburn!". Also, in "Barely Legal", Peter accidentally shoots Lois in the arm while showing off the gun he had just received from the police academy; he panics: "Oh my God, I've hit you!" and Lois responds with "I know, now stick your finger in there and twist it!"