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During Itachi's fight with Sasuke, it was revealed that Madara Uchiha and his younger brother, Izuna, were the first members of the Uchiha to activate the Mangekyo Sharingan, and used its power to take over the clan. After implanting his brother's eyes into his own body, Madara then awakened a new "Eternal" Mangekyo Sharingan, a combination of his own and Izuna's Mangekyo Sharingan which led to him acquiring immortality. so yes, but he is former of himself, so he can be defeated.

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