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SupCom has three single player campaigns, one for each faction. There's three difficulty settings as well. They're not the central focus of the game. They give some plot background for the universe, but mostly they function as training for multiplayer by introducing the units abilities, and various gameplay concepts. You can also play a skirmish against computer opponents, but again this just seems like training. As with many RTSGs, the AI strikes me as much easier to defeat than an experienced human player.
This question was asked on the wiki: Supreme Commander Wiki.