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Most female dogs come into oestrus (a "heat", or "in season") at about 8 months of age. To prevent unwanted litters, you should spay your dog at 5-6 months of age. If you plan to breed from her, you need to remember that male dogs will be able to smell her form miles away, so you should keep her inside until you find her a suitable sire. Also while she is in oestrus, she will have a bloody-like discharge (like a "period").