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Addictions have negative effects on the character in Fallout 3.
Alcohol addictions give you a -1 Agility and -1 Charisma score. Buffout addiction gives you -1 Strength, and -1 Endurance. Jet addiction gives you a -1 Agility and -1 Charisma. Mentats addiction give you -1 Intelegence and - 1 Perception. Psycho addiction gives you -1 Endurance and -1 Perception. Med-X addiction gives you -1 Agility and -1 Intelligence. Ant Nectar addiction gives you -2 Strength Nuka-Cola Quantum addiction gives you -1 Charisma and -15 Radiation Resistance.