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In the game RuneScape, the cryptic When you get tired of fighting, go deep, deep down until you need an antidote means that you should go to Yanille dungeon and fall into the place with the poison spiders, either by repeatedly walking across the balancing ledge or praying at the altar of Zamorak. Search the crate by the stairs leading up.

From the Treasure Trails guide/Cryptics article on the RuneScape Wiki.

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