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The following medications may affect how allopurinol works or increase the risk of side effects:

   * aluminum salts (e.g., antacids containing aluminum)
   * probenecid
   * salicylates (e.g., ASA)

The following medications may be affected by allopurinol:

   * ampicillin
   * amoxicillin
   * azathioprine
   * chlorpropamide
   * cyclophosphamide
   * doxorubicin
   * bleomycin
   * procarbazine
   * mechlorethamine
   * cyclosporine
   * mercaptopurine
   * phenytoin
   * theophyllines (e.g., aminophylline, oxtriphylline, theophylline)
   * vidarabine
   * warfarin

If you are taking any medications containing this drug, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

   * stop taking one of the medications,
   * change one of the medications to another,
   * change how you are taking one or both of the medications, or
   * leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. In many cases, interactions are intended or are managed by close monitoring. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription) and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or illegal drugs can affect the action of many medications, you should let your prescriber know if you use them.

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