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Head is weakest to crush type weapons (Hammers, Hunting Horns, also very weak to greatswords)
Wings are weak to pierce type weapons (Lances, Gunlance, Certain bow and bowguns shots)
Tail is weak to slashing weapons, Longsword, Great swords, Sword and Shield, Dual Blades.
Rathalos' shell isn't extremely hard, any weapon with green sharpness or better will do nicely, although weapons like sword and shield and dual blades may not have the reach to break wings or chop of tail.