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Depends if your F2P (free to play) or P2P (Members) the most defensive armor in runescape for F2P would be Rune, but as for members; I would have to say barrows.
The strongest rune armor in runescape is rune platebody, rune plate legs, Rune kite shield, Rune full helm, rune gauntlets. Ålso rune boots and rune gloves for members only.