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after rescuing red from the police station, she will express concern over the possibility of the super mutants returning. You can then offer to stay behind to defeat them, or teach the residents of big town some way to defend themselves. however, if you do not do either of these things and instead leave them to their fate, they can all be captured and dragged off by super mutants. At this point, it is impossible to rescue them and big town will be deserted forever.